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Journal of Asian Natural Products Research Volume 15, 2013 - Issue 8
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Original Articles

A concise synthesis of xestospongic acid methyl ester with pancreatic lipase inhibitory activity

Jing-Xu Gong State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China
,
He-Yao Wang State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China
,
Wen-Fei He State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; Wenzhou Medical College, Wenzhou, 325035, China
,
Zhen-Zhong Wang Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang, 222001, China
,
Wei Xiao Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang, 222001, ChinaCorrespondence[email protected]
&
Yue-Wei Guo State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, ChinaCorrespondence[email protected]
Pages 916-919 | Received 28 Nov 2012, Accepted 09 May 2013, Published online: 25 Jun 2013
 
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Abstract

Xestospongic acid methyl ester, a naturally brominated fatty acid with potent pancreatic lipase inhibitory activity in vitro, was synthesized from 5-hexynol in 30% total yield.

Acknowledgments

The research work was financially supported by the Natural Science Foundation of China (Nos 81072572, 81273430, and 21021063), National Marine ‘863’ Project (Nos 2011AA09070102 and 2013AA092902), the SKLDR/SIMM Projects (Nos SIMM1203ZZ-03, SIMM1105KF-04, and SIMM1203KF-12), W.-F.H. thanks China Postdoctoral Science Foundation Grant (No. 2012M520956).

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