Three new glucosides from a cold-adapted fungal strain Mucor sp.

Abstract

Two new naphthaline glucosides, 2-hydroxy-3-methoxy-8-methyl-1-O-β-d-glucopyranosylnaphthaline (1) and 1-hydroxy-3-methoxy-8-methyl-2-O-β-d-glucopyranosylnaphthaline (2), together with one new isocoumarin glucoside, 3-(3,3-dichloro-2-hydroxylpropyl)-6-methoxy-8-O-β-d-glucopyranosyl-1H-isochromen-1-one (3), were isolated from a cold-adapted fungal strain Mucor sp. (No. XJ07027-5). Their structures were characterized by detailed analyses of IR, MS, 1D- and 2D-NMR spectra. Among them, 2 showed moderate cytotoxic activity against five tumor cells (A-549, HL-60, MCF-7, SMMC-7721, and SW480).

Keywords::

• cold-adapted fungi
• Mucor sp
• naphthaline
• isocoumarin
• glucoside
• cytotoxic activity

Acknowledgements

This research work was financially supported by grants from the Ministry of Science and Technology of China (2009CB522300 and 2012ZX09301002-003), the program for New Century Excellent Talents in University (NCET-10-0120) from the Ministry of Education of China, and the Fundamental Research Funds for the Central Universities (21611203).

Notes

^1. These two authors contributed equally to the work reported in this article.