A new triterpenoid saponin from Ardisia gigantifolia

Abstract

A new triterpenoid saponin, named 3-O-β-d-glucopyranosyl-(1 → 3)-β-d-xylopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 3)]-β-d-glucopyranosyl-(1 → 4)-[β-d-glucopyranosyl-(1 → 2)]-α-l-arabinopyranosyl-3β,16α,28,30-tetrahydroxy-olean-12-ene (1), along with four known triterpenoids (2–5), was isolated from the rhizomes of Ardisia gigantifolia. Their structures were elucidated by spectroscopic methods. Compounds 1–4 showed cytotoxic activity against Hela, EJ, BCG, and HepG-2 cell lines. The percentage of early apoptotic cells after treatment with 1 was significantly increased compared with control cells (p < 0.05).

Keywords::

• Ardisia gigantifolia
• triterpenoid saponin
• cytotoxic activity

Acknowledgments

This work was financially supported by the National Nature Science Foundation of China (No. 31000153). The authors are grateful to Mr Li-Ping Kang for the NMR and HR-ESI-MS measurement in the Instrumentation Center of the Academy of Military Medical Sciences.

Notes

^1. These authors contributed equally to this work.