Abstract
A new protopanaxadiol-type ginsenoside, 6-O-β-d-glucopyranosyl-20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol-3-one (1), along with three known compounds, was isolated from the roots of Panax notoginseng. Their structures were determined based on some pieces of spectroscopic and chemical evidence. Compound 1 exhibited cytotoxic activity against five human cancer cell lines, with IC50 values ranging from 5.4 to 8.6 μg/ml.
Keywords::
Acknowledgements
The authors thank the National Science Foundation of China (NSFC, Grant No. 21132009). The authors are grateful to Prof. X.J. Jing for NMR measurements, Prof. J.B. Li for ESI-MS measurements, and Prof. X.G. Chen for bioassay.