Abstract
A new triterpenoid saponin, named cylindroside A (1), was isolated from the seeds of Cylindrokelupha dalatensis (Kosterm.) T.L. Wu by using chromatographic method. The structure of 1 was established by comprehensive spectroscopic analysis and chemical degradation. Compound 1 displayed significant antitumor activity in vitro against BCG and MCF-7 cancer cell lines and IC50 values were 4.17 ± 0.23 and 3.07 ± 0.66 μM by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method, respectively.
Acknowledgments
We are grateful to Professor Ping Liu and assistant researcher Li-Hua Mu of Laboratory of Clinical Pharmacology, Chinese People's Liberation Army (PLA) General Hospital, for cytotoxicity bioassays against cancer cells.