Microbial transformation of acetyl-11-keto-boswellic acid by Cunninghamella elegans

Abstract

Microbial biotransformation of acetyl-11-keto-boswellic acid by Cunninghamella elegans AS 3.1207 was carried out, and totally four transformed products were isolated. On the basis of the extensive spectral data, their structures were characterized as 7β-hydroxy-11-keto-boswellic acid (1), 7β,30-dihydroxy-11-keto-boswellic acid (2), 7β,16α-dihydroxy-3-acetyl-11-keto-boswellic acid (3), and 7β,15α,21β-trihydroxy-3-acetyl-11-keto-boswellic acid (4), respectively. Among them, products 1 and 2 are the new compounds.

Keywords::

• biotransformation
• boswellic acid
• Cunninghamella elegans AS 3.1207
• triterpenes

Acknowledgments

The authors thank the Funding Project of Competence Development Program for Beijing VET Teachers, the Scientific Research Base Fund for Science and Technology Innovation and Transformation Program, and PHR (IHLB201107151) for financial support.

Notes

^1. These two authors contributed equally to this work.