Two new compounds from an Indonesian sponge Dysidea sp.

Abstract

On our joint bioprospecting research on Indonesian marine invertebrates, we found moderate cytotoxicity on an extract of the sponge Dysidea sp. collected at Biak, West Papua. Separation of the extract provided two new compounds, biaketide (1) and debromoantazirine (2), along with four known molecules 3–6. The new structures were elucidated by spectroscopic analyses and by comparison with those reported. Compounds 1 and 2 showed moderate cytotoxicity against NBT-T2 cells with IC₅₀ values of 8.3 and 4.7 μg ml^− 1, respectively.

Keywords::

• marine natural products
• polyketide
• azirine
• cytotoxicity
• sponge

Acknowledgments

The authors thank Pharma Mar, S.A. for financial support and Mr Sandi Ardiansyah for assistance on samples collection. They also gratefully acknowledge the reviewer for critical reading and improving the manuscript.