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Articles

Two new compounds from Crataegus pinnatifida and their antithrombotic activities

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Pages 169-174 | Received 26 Jun 2013, Accepted 22 Sep 2013, Published online: 25 Oct 2013
 

Abstract

One new sesquiterpene, (1α,4aβ,8aα)-1-isopropanol-4a-methyl-8-methylenedecahydronaphthalene (1), with one new phenylpropanoid, threo-2-(4-hydroxy-3,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-1-ol (2), along with four known phenylpropanoids were isolated from Crataegus pinnatifida. The structures of compounds 1 and 2 were elucidated on the basis of 1D, 2D NMR analyses, and HR-ESI-MS. The antithrombotic activity in vitro of all isolates was assayed, and only compound 1 exhibited potent antithrombotic activity by inhibiting platelet aggregation in rat plasma by 81.4% at 1 mg/ml.

Acknowledgments

This work was financially supported by the National Natural Youth Science Foundation of China (No. 81302661), the Scientific Research Starting Foundation for Doctors (No. 20121106) and the Foundation from the Project of Education Department of Liaoning Province of China (No. L2012358). The authors thank Senior Engineer W. Li and Senior Engineer Y. Sha of Shenyang Pharmaceutical University for supporting the recording of NMR spectra.

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