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Journal of Asian Natural Products Research Volume 16, 2014 - Issue 2
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Articles

Two new degradative cassane-type diterpenes isolated from Caesalpinia minax

Zhao-Cui SunKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China
,
Guo-Xu MaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China
,
Jing-Quan YuanNational Engineering Laboratory of Southwest Endangered Medicinal Resources Development, National Development and Reform Commission, Guangxi Botanical Garden of Medicinal Plant, Nanning, 530023, China
,
Hua WeiInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China
,
Hai-Feng WuKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China
,
Zhong-Hao SunKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China
,
Guo-Hong WangDepartment of Pharmacy, Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan, 030012, China
,
Jun-Shan YangKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China
&
Xu-Dong XuKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, ChinaCorrespondence[email protected]
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Pages 187-191 | Received 26 Aug 2013, Accepted 06 Nov 2013, Published online: 11 Dec 2013
 
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Abstract

Cassane-type diterpenes are main bioactive constituents of Caesalpinia minax HANCE. As a part of our ongoing chemical investigation of C. minax, two new degradative cassane-type diterpenes, named caesalpins I (1) and J (2), were isolated from the EtOAc extract of the seeds of C. minax. The structures were elucidated by means of spectroscopic analysis.

Acknowledgments

The work was financially supported by the technological large platform for comprehensive research and development of new drugs in the Eleventh Five-Year “Significant New Drugs Created” Science and Technology Major Projects (No. 2009ZX09301-003), the National Natural Science Foundation of China (No. 30973626), Innovation Capacity-building in Guangxi Science and Technology Agency (No. 10100027-3), the National Science and Technology Support Program (No. 2012BA127B06), the Guangxi Science and Technology Achievements Transformation Project (No. 1298009-22), and the Scientific and Technological Project in Nanning City (No. 201102088C).

Notes

1. These authors contributed equally to this work.

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