Abstract
Laggeric acid (1), a novel 4,5-seco-eudesmane sesquiterpene acid, along with 19 known compounds, was isolated from the MeOH extract of the whole plant of Laggera crispata. The structure of 1 was elucidated to be (4S,5S*,7R*,10R*)-4,5-seco-4,5-dihydroxy-11(13)-eudesmen-12-oic acid on the basis of spectroscopic analysis and a convenient Mosher's method.
Acknowledgments
The authors thank the National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program”, China (No. 2012ZX09301001-001), and the National Natural Science Foundation of China (Nos 81072545 and 21202182) for the financial supports. The authors thank the National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program”, China (No. 2012ZX09301001-001), and the National Natural Science Foundation of China (Nos 81072545 and 21202182) for the financial supports.
Notes
1. These authors contributed equally to this work.