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Journal of Asian Natural Products Research Volume 16, 2014 - Issue 3
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Articles

A new dihydroagarofuranoid sesquiterpene from the roots of Tripterygium hypoglaucum

Zhen-Zhen LiuInstitute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100193, China;College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, 650500, China
,
Rong-Hua ZhaoCollege of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, 650500, China
,
Yue-Tao LiuInstitute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100193, China
,
Hong-Wu ZhangInstitute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100193, China
,
Gang DingInstitute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100193, China
,
Zhuo MaCollege of Biological Engineering, Hubei University of Technology, Wuhan, 430068, ChinaCorrespondence[email protected] [email protected]
&
Zhong-Mei ZouInstitute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100193, ChinaCorrespondence[email protected] [email protected]
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Pages 327-331 | Received 10 Sep 2013, Accepted 03 Dec 2013, Published online: 23 Jan 2014
 
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Abstract

A new sesquiterpene ester (1) has been isolated from the root bark of Tripterygium hypoglaucum. The structure was determined as 1α-acetoxy-6β,9β-dibenzoyloxy-4β-hydroxy-dihydroagarofuran by the extensive analysis of NMR data, and the absolute configurations were established as 1R, 4R, 6S, and 9R by application of the CD excitation chirality method. Compound 1 exhibited weak cytotoxicity against HeLa cells, with an IC50 value of 30.2 μM.

Acknowledgments

We gratefully acknowledge financial support from Chinese National S&T Special Project on Major New Drug Innovation (2011ZX09307-002-01) and Program for Innovative Research Team in IMPLAD.

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