Design, synthesis and evaluation of 9-hydroxy-7H-furo[3,2-g]chromen-7-one derivatives as new potential vasodilatory agents

Abstract

Two new 9-hydroxy-7H-furo[3,2-g]chromen-7-one derivatives were designed, synthesized and evaluated for their in vitro vasodilatory activity. The structures of two compounds were elucidated by infrared, ¹H NMR, and mass spectral data. The invitro pharmacological evaluation indicated that both of them possessed well vasodilatory activity compared with imperatorin. The molecule docking also showed two target compounds docked well with L-calcium channel (PDB code: 3G43). The result suggested that they would be potential vasodilatory agents for hypertension.

Keywords::

• 9-hydroxy-7H-furo[3,2-g]chromen-7-one
• vasodilatory activity
• synthesis
• molecule docking

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Nos 81202494, 30730110) and the Intramural Research Foundation of Xi'an Jiaotong University (Grant No. xjj2012048).