Ionone glycosides from the roots of Rehmannia glutinosa

Abstract

Four new ionone and ionone glycosides (1–4), and a new monoterpene (5), together with 10 known analogues (6–15), were isolated from the air-dried roots of Rehmannia glutinosa. The structures of these compounds were elucidated on the basis of spectroscopic data analysis. Furthermore, in in vitro assays, compound 3 (10 μM) exhibited moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage.

Abstract

Keywords::

• Rehmannia glutinosa
• ionone glucoside
• hepatoprotective

Acknowledgements

The project was financially supported by the National Science and Technology Project of China (Grant No. 2011ZX09307-002-01) and the State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College.