Abstract
A novel series of N-methyl-bisindolylmaleimides were synthesized and evaluated for their inhibitory activities against nine tumor cell lines. Some of the compounds showed an interesting activity against the tested cell lines. The most potent compounds 5e and 5j displayed antiproliferative activity with 50% inhibitory concentration values in the μM range against some tested cell lines.
Acknowledgement
The research was financially supported by the Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation.