A novel 6-hydroxy-8,11,11-trimethyl-bicyclo[7.2.0]undec-4-ene-4-carboxylic acid: a potent antioxidant agent from Iphiona scabra

Abstract

A novel 6-hydroxy-8,11,11-trimethyl-bicyclo[7.2.0]undec-4-ene-4-carboxylic acid 1 has been isolated from leaves of Iphiona scabra DC. Its structure has been established on the basis of chemical and physical evidence (IR, ¹H NMR, ¹³C NMR, and MS) and further confirmed by single-crystal X-ray diffraction study. The in vitro antioxidant activities of isolated compound 1 and extracts were evaluated by 1,1-diphenyl-2-picrylhydrazyl method.

Keywords::

• Iphiona
• Compositae
• X-ray crystallographic study
• antioxidant activity

Acknowledgements

The authors thank the Chairman, Department of Chemistry for providing necessary research facilities and P.S. Pereira Silva for the providing support by Fundação para a Ciência e a Tecnologia, under the scholarship SFRH/BPD/84173/2012.

Supplementary material

Crystallographic data for structural analysis have been deposited at the Cambridge Crystallographic Data Center, CCDC No. 934640. Copies of this information may be obtained free of charge on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (Fax: [phone]; Email: [email protected] or http://www.ccdc.cam.ac.uk).