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Articles

An efficient synthesis method targeted to marine alkaloids marinacarbolines A–D and their antitumor activities

, , , , &
Pages 299-305 | Received 27 Oct 2014, Accepted 07 Dec 2014, Published online: 28 Jan 2015
 

Abstract

Marinacarbolines A–D are a series of marine β-carboline alkaloids isolated from actinomycete Marinactinospora thermotolerans of the deep South China Sea with antiplasmodial activities. In inhibition assays of in vitro growth of Plasmodium falciparum, marinacarbolines exhibited antiplasmodial activity against drug-sensitive line 3D7 and drug-resistant line Dd2 of P. falciparum. However, approaches for the synthesis of such useful compounds are very limited. In this work, we reported a simple, efficient, and versatile process to synthesize marinacarbolines A–D (14). On the basis of that, the antitumor activities of marinacarbolines in a structure-dependent manner were allowed to be unveiled.

Notes

1. These authors contributed equally to this work.

Additional information

Funding

This research was supported by Natural Science Foundation of China [grant number 21171154], [grant number 91129706]; and NSFC-Shandong Joint Fund for Marine Science Center [U1406402].

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