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Journal of Asian Natural Products Research Volume 16, 2014 - Issue 4
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Microbial transformation of oleanolic acid by Trichothecium roseum

Ting GongState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China;Key Laboratory of Biosynthesis of Natural Products of the National Health and Family Planning Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
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Li ZhengState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China;Key Laboratory of Biosynthesis of Natural Products of the National Health and Family Planning Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
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Xin ZhenState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China;Key Laboratory of Biosynthesis of Natural Products of the National Health and Family Planning Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
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Hui-Xia HeState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China;Key Laboratory of Biosynthesis of Natural Products of the National Health and Family Planning Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
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Hui-Xin ZhuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China;Key Laboratory of Biosynthesis of Natural Products of the National Health and Family Planning Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China
&
Ping ZhuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, China;Key Laboratory of Biosynthesis of Natural Products of the National Health and Family Planning Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100050, ChinaCorrespondence[email protected]
Pages 383-386 | Received 02 Dec 2013, Accepted 14 Jan 2014, Published online: 10 Feb 2014
 
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Abstract

Microbial transformation of the oleanolic acid (1) using Trichothecium roseum (pers.) Link (M 95.56) has resulted in the isolation of two new hydroxylated type metabolites, characterized as 15α-hydroxy-3-oxo-olean-12-en-28-oic acid (2) and 7β,15α-dihydroxy-3-oxo-olean-12-en-28-oic acid (3). The structure elucidation of these metabolites was based primarily on HR-EIMS, 1D NMR, and 2D NMR analyses.

Acknowledgments

This work was financially supported by grant from the Mega-project for Innovative Drugs (No. 2012ZX09301002-001-005) and the Fundamental Research Funds for the Central Universities (2012N06). The authors are grateful to the Department of Instrumental Analysis of our Institute for measurement of the IR, NMR, and MS data.

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