A new compound from an endophytic fungus Alternaria tenuissima

Abstract

A new secondary metabolite, named altertoxin IV (1), together with altertoxin II (2), was isolated from the fermentation broth of Alternaria tenuissima, an endophytic fungal strain residing in the stem of Tribulus terrestris L. The structure of new compound 1 was established by HR-ESI-MS, multinuclear NMR spectroscopy, and single crystal X-ray diffraction method. In their in vitro bioassay, compound 2 exhibited moderate cytotoxic activity against PC-3 cell lines with an IC₅₀ value of 14.28 μM.

Keywords::

• Alternaria tenuissima
• endophytic fungus
• altertoxin IV
• cytotoxicity

Acknowledgments

This work was financially supported by National Science Foundation (No. 61172149) and Science Foundation from the Science and Technology Committee of Shanghai Municipality (No. 11DJ1400101).