Jaspiferins C–F, four new isomalabaricane-type triterpenoids from the South China Sea sponge Jaspisstellifera

Abstract

A chemical investigation of marine sponge Jaspis stellifera, collected from the South China Sea, led to the isolation of four new isomalabaricane-type triterpenoids, jaspiferins C–F (1–4). The structures of those compounds were elucidated by extensive spectroscopic methods. Jaspiferin C (1), which has the six-membered carbon ring at the side chain, was discovered for the first time from the isomalabaricane-type triterpenoids. The hypothesis of a biogenetic pathway to generate jaspiferin C (1) was depicted.

Keywords::

• marine sponge
• Jaspis stellifera
• isomalabaricane triterpenoid
• structural elucidation

Acknowledgments

This work was partially supported by the National Natural Science Foundation of China (Grant No. 81102371) and the Natural Science Foundation of Tianjin, China (Grant No. 10JCYBJC15000).