Advanced search
Publication Cover
Journal of Asian Natural Products Research Volume 16, 2014 - Issue 7
Submit an article Journal homepage
187
Views
2
CrossRef citations to date
0
Altmetric
Articles

Synthesis and bioactivity of diketopiperazine PJ147 and its derivatives from Gliocladium sp. YUP08

Xue-Zheng LiDepartment of Pharmacy, Affiliated Hospital of Yanbian University, Yanji133000, China
,
Gang ChenSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang110016, ChinaCorrespondence[email protected]
,
Hai-Feng WangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang110016, China
,
Hui-Ming HuaSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang110016, China
&
Yue-Hu PeiSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang110016, China
Pages 764-769 | Received 16 Oct 2013, Accepted 15 Apr 2014, Published online: 14 May 2014
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Concise total synthesis of diketopiperazine PJ147, obtained from mycelium of Gliocladium sp. YUP08, has been achieved in seven steps with 43.5% overall yield. Biological evaluation of PJ147 exhibited strong inhibiting activity against A375-S2, Hela, P388, A-549, HL-60, and BEL-7420 cell lines. Thus, eight derivatives of PJ147 with high water solubility were also synthesized to facilitate the in vivo bioassay of this kind of diketopiperazines.

Acknowledgments

This paper was financially supported by projects of Shenyang science and technology plans F12-156-9-00 and by Program for Innovative Research Team of the Ministry of Education and Program for Liaoning Innovative Research Team in University.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.