New triterpenoids with protein tyrosine phosphatase 1B inhibition from Cedrela odorata

Abstract

Two new apotirucallane-type triterpenoids, cedrodorols A–B (1 and 2), along with seven known compounds (3–9), were isolated from the twigs and leaves of Cedrela odorata. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with the IC₅₀ values of 13.09 and 3.93 μg/ml, respectively.

Keywords::

• Cedrela odorata
• Meliaceae
• triterpenoid
• PTP1B inhibitor

Acknowledgments

This project was financially supported by the National Natural Science Foundation (No. 21272244) and the Foundation (No. 2012CB721105) from the Ministry of Science and Technology of the People's Republic of China. We thank Prof. You-Kai Xu for the identification of the plant material.