Three new cyclopentenone derivatives from Actinoalloteichus nanshanensis NEAU 119

Abstract

Three new cyclopentenone derivatives (1–3) were isolated from the rare actinomycete Actinoalloteichus nanshanensis NEAU 119. Their structures were elucidated by extensive spectroscopic analysis. Compound 1 showed moderate cytotoxic activity against human lung adenocarcinoma cell line A549, human leukemia cell line K562, and human renal carcinoma cell line ACHN with an IC₅₀ of 14.67, 11.87, and 23.36 μg ml^− 1, respectively.

Keywords::

• Actinoalloteichus nanshanensis NEAU 119
• cyclopentenone
• cytotoxic activity

Acknowledgment

This work was financially supported by the National Outstanding Youth Foundation (31225024), the National Key Project for Basic Research (2010CB126102), the National Key Technology R&D Program (2012BAD19B06), the National Natural Science Foundation of China (31372006, 31171913 and 31071750), the Program for New Century Excellent Talents in University (NCET-11-0953), the Outstanding Youth Foundation of Heilongjiang Province (JC201201), and Chang Jiang Scholar Candidates Program for Provincial Universities in Heilongjiang (CSCP).