A new symmetrical tetramer oligostilbenoid containing tetrahydrofuran ring from the stem bark of Dryobalanops lanceolata

Abstract

A new tetramer oligostilbenoid possessing tetrahydrofuran ring, malaysianol C (1), was isolated from the acetone extract of the stem bark of Dryobalanops lanceolata, together with four known oligostilbenoids nepalensinol E (2), ϵ-viniferin (3), laevifonol (4), and ampelopsin F (5). The structures of isolated compounds were elucidated on the basis of spectral evidence. The antibacterial activity of the isolated compounds was evaluated using resazurin microtitre-plate assay, whereas the cytotoxic activity was tested using MTT assay. The plausible biogenetic routes of the isolated compounds are also discussed.

Keywords::

• Dipterocarpaceae
• Dryobalanops lanceolata
• oligostilbenoid
• malaysianol C
• antibacterial
• cytotoxicity

Acknowledgments

The authors would like to thank The Ministry of Higher Education, Malaysia for the financial support under the Fundamental Research Grant Scheme [600-RMI/ST/FRGS/5/3/FST (12/2010)], and Prof. Dr Teh Lay Kek, Pharmacogenomics Institute (iPROMISE), UiTM Puncak Alam, Malaysia for the mass spectrometer measurement of samples.