Abstract
A novel oxybis cresol compound named verticilatin (1), together with two known compounds, 5-methylresorcinol (2) and 2,4-dihydroxy-3,6-dimethylbenzaldehyde (3), was isolated from cultures of the insect pathogenic fungi Paecilomyces verticillatus. The structures of compounds were determined by extensive spectroscopic analysis of HR-ESI-MS and 1D and 2D NMR including HSQC, HMBC, COSY, and ROESY. Fortunately, compound 1 exhibited significant inhibitory activities against CDC25B, cathepsin B, MEG2, and SHP2 enzyme, with IC50 values of 11.5, 3.5, 7.8, and 15 μg/ml, respectively.
Acknowledgments
This work was financially supported by National Natural Science Foundation of China (Nos 31171885 and 31371957), Changjiang Scholars and Innovative Research Team in University (No. IRT1124), The Ph.D. Programs Foundation of Ministry of Education of China (No. 20121301110006), and Key Projects in the Hebei Province Science & Technology (No. 13226508D).