Two new phenol derivatives from Stereum hirsutum FP-91666

Abstract

Two new phenol derivatives, 2-(3-methyl-2-buten-1-yl)-4-methoxyethyl-phenol (1) and 5-hydroxy-4-(hydroxymethyl)-2-(3-methylbut-2-en-1-yl)cyclohex-4-en-1-one (2), together with eight known compounds consisting of phenol derivatives (3 and 4), niacinamide (5), and five ergosta type compounds (6–10), were isolated from solid fermentation products of Stereum hirsutum FP-91666. Two new structures were elucidated by extensive spectroscopic methods, including 1D NMR and 2D NMR, and HR-EI-MS experiments.

Keywords::

• Stereaceae
• Stereum hirsutum FP-91666
• 2-(3-methyl-2-buten-1-yl)-4-methoxyethyl-phenol
• 5-hydroxy-4-(hydroxymethyl)-2-(3-methylbut-2-en-1-yl)cyclohex-4-en-1-one

Acknowledgments

The strain S. hirsutum FP-91666 was obtained as a gift from culture collection manager Ms Rita Rentmeester of Center for Forest Mycology Research, Northern Research Station, Madison, WI, USA. This work was supported by grants from the “973” Program of China (2013CB127505), the NSFC (31170061), and Applied Basic Research Foundation of Yunnan Province (2013FA018), the Young and Technical Leader Raising Foundation of Yunnan Province (2009CI071). We acknowledge the Department of Instrumental Analysis of Kunming Institute of Botany for measuring the optical rotations, UV, NMR, and mass spectra.