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Journal of Asian Natural Products Research Volume 17, 2015 - Issue 1
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Reviews

Hepatic metabolism: a key component of herbal drugs research

Yu-Shuai PengSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing100102, China
,
Bin LiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing100102, China
,
Ru-Feng WangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing100102, ChinaCorrespondence[email protected] [email protected]
,
Qi-Tao ZhaoSchool of Basic Medicine, Shandong University of Traditional Chinese Medicine, Jinan250355, China
,
Wei XuState Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing100191, China
&
Xiu-Wei YangState Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing100191, ChinaCorrespondence[email protected] [email protected]
Pages 89-106 | Received 12 May 2014, Accepted 28 Aug 2014, Published online: 08 Oct 2014
 
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Abstract

Liver is the largest metabolic organ for a wide range of endogenous and exogenous compounds and plays a crucial part in the pharmacokinetics and pharmacodynamics through various metabolic reactions. This review provides a progressive description of hepatic metabolism of herbal drugs with respect to metabolic types and investigational methods. In addition, the problems encountered during the research process are discussed.

Acknowledgements

This work was financially supported by NSFC (No. 81073018 and No. 81274044).

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