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Journal of Asian Natural Products Research Volume 17, 2015 - Issue 4
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A new α-pyrone metabolite from a mangrove plant endophytic fungus, Fusarium sp.

Yoshihito ShionoDepartment of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata997-8555, JapanCorrespondence[email protected]
,
Fumiaki ShibuyaDepartment of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata997-8555, Japan
,
Takuya KosekiDepartment of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata997-8555, Japan
,
HarizonDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang45363, Indonesia
,
Unang SupratmanDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang45363, Indonesia
,
Shota UesugiLaboratory of Chemical Biology, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate020-8550, Japan
&
Ken-ichi KimuraLaboratory of Chemical Biology, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate020-8550, Japan
 show all
Pages 403-408 | Received 30 May 2014, Accepted 31 Aug 2014, Published online: 30 Oct 2014
 
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Abstract

A new α-pyrone derivative, compound 2, and a known one, cladobotrin V, were isolated from the culture broth of the mangrove endophyte Fusarium sp. IM-37. Their structures were determined spectroscopically and compared with previously reported spectral data. Compound 2 restored the growth inhibition caused by hyperactivated Ca2+-signaling in mutant yeast.

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