New tricycloalternarenes from fungus Alternaria sp.

Abstract

Two new tricycloalternarenes I (1) and J (2), together with five known derivatives (3–7), were isolated from the culture of marine fungus Alternaria sp. The structures were elucidated by a combination of spectroscopic approach (¹H, ¹³C NMR, HMBC, COSY, and NOESY) and the low-temperature (100 K) single-crystal X-ray crystallography analysis. The antimicrobial assays of tricycloalternarenes I (1) and J (2) were tested.

Keywords::

• marine-derived fungi
• Alternaria sp.
• phytotoxins
• tricycloalternarenes derivatives

Acknowledgments

This work was financed by the National Natural Science Foundation of China (81172948, 81121062 and 21132004) and the National High Technology Research and Development Program of China (863 Program, 2013AA092901).

Supplementary information

Supplementary data associated with this article can be found in the online version along with Figures S1–S11.