Dihydroxanthenones from the fermentation product of an endophytic fungus Gliomastix murorum

Abstract

Three new dihydroxanthones, muroxanthenones A–C (1–3), together with three known dihydroxanthones (4–6) were isolated from the fermentation products of an endophytic fungus Gliomastix murorum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 3 showed high cytotoxicities against NB4 and PC3 cell with IC₅₀ values of 2.2 and 2.8 μM. The other compounds also showed moderate cytotoxicities for some tested cell lines with IC₅₀ values between 4.1 and 9.5 μM.

Keywords::

• dihydroxanthenone
• Gliomastix murorum
• structure elucidation
• cytotoxicity

Acknowledgements

This research was supported by the National Natural Science Foundation of China (No. 21462051), the Applied Basic Research Combined Project of Yunnan Technology Bureau and Kunming Medical University (No. 2011FB124), and the Scientific Research Fund Key Project of Education Department of Yunnan Province (No. 2013Z038).