Bioactive triterpenoids from Atriplex lasiantha

Abstract

Chromatographic purification of the ethyl acetate soluble fraction from the methanolic extract of Atriplex lasiantha yielded a new triterpenoid, 7β,15α,16β-trihydroxyolean-12-ene-28,30-dioic acid-3-O-β-d-xylopyranoside (1), along with two known triterpenoids, rotundifolioside I (2) and corchorusin B (3). Structures of the compounds 1–3 were elucidated through sophisticated NMR studies and high resolution mass spectrometry. The three isolates (1–3) were evaluated for antibacterial, antioxidant, and antiurease activities. Compound 2 exhibited the best antibacterial activity against Escherichiacoli with IC₅₀ value of 66.25 μg/ml, whereas, all the tested compounds exhibited antioxidant (IC₅₀ values of 68.7–75.4 μg/ml) and antiurease (IC₅₀ values of 25.5–49.3 μg/ml) activities, respectively.

Keywords::

• Atriplex lasiantha
• triterpenoid
• charaterization
• biological activities

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Mr Basharat Ali is thankful to Higher Education Commission of Pakistan for a scholarship support, whereas, Dr Muhammad Saleem and Dr Naheed Riaz acknowledge AvH Foundation, Germany for providing necessary equipment to complete this work.