Two new secondary metabolites from the marine-derived fungus Nigrospora sphaerica

Abstract

Two new secondary metabolites, (2S)-5-acetamidopentyl-2-hydroxypropanoate (1) and 2, 5, 7-trihydroxy-4-(3′-methylbut-2′-en-1′-yl) oxy-2H-naphtho [1, 8-b c] furan-9-one (2) were isolated from the marine-derived fungus Nigrospora sphaerica. The structures were established on the basis of their spectroscopic data, including 1D NMR and 2D NMR, HR-TOF-MS, and the absolute configuration of compound 1 was determined by the Mosher method.

Keywords::

• marine natural product
• Nigrospora sphaerica
• (2S)-5-acetamidopentyl-2-hydroxypropanoate
• phenalenone derivative

Additional information

Funding

This work was financially supported by the Fundamental and Frontier Research Fund of Chongqing under [grant number cstc2014jcyjA10108]; Fundamental Research Funds for the Central Universities under [grant number CQDXWL-2014-Z007]; Special Fund for Basic Scientific Research of Central Colleges, Chongqing University under [grant number 201310611045] and Fundamental Research Funds for the Central Universities under [grant number CQDXWL-2012-031].