Hepatoprotective benzofurans and furanolignans from Gymnema tingens

Abstract

Two new benzofurans, gymnefuranols A (1) and B (2), together with six known furanolignans (3–8), were isolated from Gymnema tingens. The structures of the new compounds were elucidated by comprehensive analysis of the NMR and HR-MS data. Compounds 1, 2, 6, and 7 showed hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.

Keywords::

• Asclepiadaceae
• Gymnema tingens
• hepatoprotective
• benzofuran
• furanolignan
• structure elucidation

Acknowledgements

We thank Professor W.Y. She for measuring the NMR spectra.

Disclosure Statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Science and Technology Project of China [grant number 2012ZX09301002-002] and PCSIRT [grant number IRT1007].