Four lanostane-type triterpenes from the fruiting bodies of mushroom Laetiporus sulphureus var. miniatus

Abstract

Two new 3,4-seco-lanostane-type triterpenes, named as 15α-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1), 5α-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid 3-methyl ester (2), and one new lanostane triterpene 15α-acetoxylhydroxytrametenolic acid (3) together with a known one versisponic acid D (4) were isolated from the fruiting bodies of Laetiporus sulphureus var. miniatus. Their structures were determined on the basis of extensive spectroscopic methods and comparison with reported data. All four compounds were evaluated for their cytotoxicities against five human cancer cell lines; however, none exhibited inhibitory effects.

Keywords::

• basidiomycetes
• Laetiporus sulphureus
• lanostane-type triterpenes
• cytotoxicities

Acknowledgments

The authors are grateful to Kunming Institute of Botany, Chinese Academy of Sciences, for the measurement of all spectroscopic data.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Natural Science Foundation of Yunnan Province [grant number 312011FB099].