Nodulisporipyrones A–D, new bioactive α-pyrone derivatives from Nodulisporium sp.

Abstract

Four new α-pyrone derivatives, nodulisporipyrones A–D (1–4), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (65-12-7-1) that was fermented with rice. The structures of 1–4 were elucidated by extensive spectroscopic analysis, and the absolute configurations were determined by modified Mosher's method and electronic circular dichroism experiments. Their antimicrobial activities against Staphylococcus aureus 209P, Escherichia coli ATCC0111, Aspergillus niger R330, and Candida albicans FIM709 were evaluated using a paper disk diffusion method. Nodulisporipyrones A–D (1–4) are the first α-pyrone derivatives from Nodulisporium fungi.

Keywords::

• Nodulisporium sp.
• endolichenic fungus
• α-pyrone
• nodulisporipyrone
• antimicrobial activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

Dedicated to Professor Xin-Sheng Yao on the occasion of his 80th birthday.

^1. These authors contributed equally to this work.

Additional information

Funding

This work was financially supported by grants from the Ministry of Science and Technology of China [grant number 2012ZX09301002-003001006], the National Natural Science Foundation of China [grant number 81422054 and grant number 81373306], the Guangdong Natural Science Funds for Distinguished Young Scholar [grant number S2013050014287], Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (Hao Gao, 2014), and the Dean Foundation of South China Agricultural University [grant number ZHXY2013A02].