An unusual dihydrobenzofuroisocoumarin and ent-kaurane diterpenoids from Pteris multifida

Abstract

An unusual 5-C-methylated-dihydrobenzofuroisocoumarin, named multifidarin A (1), and two new ent-kaurane diterpenoids, named multikauranes A (2) and B (3), together with three known ent-kaurane diterpenoids, were isolated from the whole plants of Pteris multifida. The structures of 1–3 were elucidated by spectroscopic methods. The cytotoxic activities of all new compounds were evaluated against five human tumor cell lines. A possible biosynthetic process for the formation of 1 is proposed.

Keywords::

• Pteridaceae
• Pteris multifida
• isocoumarin
• ent-kaurane diterpenoids
• multifidarin A
• multikaurane

Acknowledgment

This research was financially supported by the National Natural Science Foundation of China (No. 21132009), the National Mega-Project for Innovative Drugs (No. 2012ZX09301002001003), and the Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education.

Disclosure statement

No potential conflict of interest was reported by the authors.