Two new monoterpenoid α-pyrones from a fungus Nectria sp. HLS206 associated with the marine sponge Gelliodes carnosa

Abstract

Two new monoterpenoid α-pyrones, named nectriapyrones C and D (1 and 2), along with a known α-pyrone (nectriapyrone, 3) were isolated from a marine-derived fungus Nectria sp. HLS206 associated with the marine sponge Gelliodes carnosa collected from the South China Sea. Their structures were determined on the basis of 1D NMR, 2D NMR, HR-ESI-MS methods.

Keywords::

• marine fungus
• Nectria sp
• secondary metabolites
• monoterpenoid α-pyrones

Acknowledgments

We acknowledge the Research Team of Professor Xiao-guang Chen, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, and Peking Union Medical College for cytotoxicity bioassays. We are grateful to the Department of Instrumental Analysis of our Institute for measurement of the IR, NMR, and MS data.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by grant from the Mega-project for Inovative Drugs [grant number 2012ZX09301002-001-005] and National Natural Science Foundation of China [grant number 81402846].