Three decomposition products of valepotriates from Valeriana jatamansi and their cytotoxic activity

Abstract

Three new decomposition products of valepotriates, valtrals A–C (1–3), and two known products, baldrinal and homobaldrinal, are formed during the isolation procedure of the ethanol extract of the whole plants of Valeriana jatamansi. Their structures were determined by spectroscopic methods including IR, MS, 1D, and 2D NMR experiments. Compounds 1–3 showed selective cytotoxicity against metastatic prostate cancer (PC-3M) and colon cancer (HCT-8) cell lines.

Keywords::

• Valeriana jatamansi
• valepotriates
• valtrals A–C
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by program NCET Foundation, NSFC [grant number 81230090]; Shanghai Leading Academic Discipline Project [grant number B906]; Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [grant number 10DZ2251300]; the Scientific Foundation of Shanghai China [grant number 12401900801], [grant number 13401900101]; National Major Project of China [grant number 2011ZX09307-002-03]; and the National Key Technology R&D Program of China [grant number 2012BAI29B06].