A new trichostatin analog from Streptomyces sp. CPCC 203909

Abstract

A new trichostatin analog (1) and two known analogs (2, 3) have been isolated from the rice fermentation of the Streptomyces sp. CPCC 203909. Their structures were determined by spectroscopic and chemical methods. The absolute configurations of 1 were assigned by Marfey's method, combined with comparing the NMR and circular dichroism spectroscopic data of 2 and 3. Compound 1 showed cytotoxicity against human embryonic kidney 293 cell line with IC₅₀ value of 39.2 μM.

Keywords::

• trichostatin analog
• Streptomyces sp
• Marfey's method
• circular dichroism spectroscopic data
• cytotoxicity

Funding

Financial support from the Beijing Natural Science Foundation [grant number 7144224]; the National Natural Sciences Foundation of China [NNSFC; grant number 81302675]; the National Science and Technology Project of China [grant number 2012ZX09301002-003]; and National Infrastructure of Microbial Resources is acknowledged.

Disclosure statement

No potential conflict of interest was reported by the authors.