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Abstract
Three new cyathane diterpenoids, cyathin W (1), cyathin V (2), and cyathin T (3), were isolated from the solid culture of Cyathus africanus. The structures and configurations of these new compounds were elucidated on the basis of comprehensive spectroscopic analysis including 1D NMR, 2D NMR (HSQC, HMBC, NOESY), and HR-ESI-MS experiments. Compounds 1 and 3 showed moderate inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with IC50 value of 80.07 and 88.87 μM, respectively. In cytotoxicity assay, compound 1 showed weak cytotoxicity against K562 cell line with IC50 value of 12.1 μM.
Disclosure statement
No potential conflict of interest was reported by the authors.
Notes
1. To celebrate the 80th birthday of Prof. Xin-sheng Yao.
Additional information
Funding
This research was financially supported by the following funds including Screening and Potential Valuation of Marine Microbes for Agriculture Application (China Ocean Mineral Resources R&D Association) [grant number DY125-15-T-07], the National Natural Science Foundation of China [grant number 21472233], [grant number 81473119], [grant number 81473590], [grant number 81274115], [grant number 81102343]; China–Japan Friendship Hospital Youth Science and Technology Excellence Project [grant number 2014-QNYC-B-10], [grant number 2013-MS-34]; Program for New Century Excellent Talents in University of the Chinese Ministry of Education [grant number NCET-11-0606]; and Program for Excellent Talents of Beijing Municipal Party Committee Organization Department of the Communist Party of China [grant number 2013D009999000001].