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Journal of Asian Natural Products Research Volume 17, 2015 - Issue 5: Celebration to Professor Xinsheng Yao's 80th birthday
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Spiroalkaloids from Shensong Yangxin capsule

Bo DingGuangdong Institute for Food and Drug Control, Guangzhou510180, China;Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, ChinaView further author information
,
Yi DaiInstitute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, ChinaCorrespondence[email protected] [email protected]
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Yun-Long HouState-Province Key Laboratory of Biomedicine-Pharmaceutics of China, Department of Pharmacology, Harbin Medical University, Harbin150086, ChinaView further author information
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Xin-Sheng YaoInstitute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, China;Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected] [email protected]
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Pages 559-566 | Received 30 Jan 2015, Accepted 27 Apr 2015, Published online: 13 Jul 2015
 
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Abstract

Four spiroalkaloids, including a new compound shensongine A (1), were isolated from the anti-arrhythmic TCM formula Shensong Yangxin capsule. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 3 displayed cardiovascular activities by shortened APD in rat myocardial cells. These compounds were possibly generated from precursors in different composed herbal medicines during the processing of the TCM formula.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Notes

This paper is dedicated to Professor Xin-Sheng Yao on the occasion of his 80th birthday.

Additional information

Funding

This work was financially supported by grants from the Ministry of Science and Technology of China with the Key Drug Discovery Project of 12th Five-year plan [grant number 2011ZX09201-201-28].

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