Pericoterpenoid A, a new bioactive cadinane-type sesquiterpene from Periconia sp.

Abstract

Pericoterpenoid A (1), a new cadinane-type sesquiterpene, was isolated from an endolichenic fungal strain Periconia sp. (No. 19-4-2-1). Its structure was characterized by analyzing the spectroscopic data (IR, MS, 1D- and 2D-NMR). The antimicrobial activity against Escherichia coli, Staphylococcus aureus, Aspergillus niger, and Candida albicans was evaluated. Pericoterpenoid A showed moderate antimicrobial activity against A. niger and weak activity against C. albicans. This is the first report of the presence of cadinane-type sesquiterpene in Periconia sp.

Keywords::

• Periconia sp
• endolichenic fungus
• cadinane-type sesquiterpene
• pericoterpenoid A
• antimicrobial activity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Notes

Dedicated to Prof. Xin-Sheng Yao on the occasion of his 80th birthday.

^1. These authors contributed equally to this work.

Additional information

Funding

This work was financially supported by the Ministry of Science and Technology of China [grant number 2012ZX09301002-003001006], the National Natural Science Foundation of China [grant number 81422054], [grant number 81373306], the Guangdong Natural Science Funds for Distinguished Young Scholar [grant number S2013050014287], Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme, and the State Key Laboratory of Pharmaceutical Biotechnology [grant number KF-GN-201412].