Carbazole and amide alkaloids from the stems of Clausena lansium

Abstract

Two new carbazole alkaloids, claulansine S (1) and claulansine T (2), and one new amide alkaloid, clauamide A (3), together with four known analogues (4–7) were isolated from the stems of Clausena lansium. Their structures were elucidated on the basis of spectroscopic analyses, including UV, IR, and NMR experiments (HSQC, HMBC, and NOE experiments). Compounds 4 and 6 showed moderate hepatoprotective activities.

Keywords::

• Rutaceae
• Clausena lansium
• alkaloids
• hepatoprotective

Acknowledgments

We are grateful to the Department of Instrumental Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, for the measurement of the UV, IR, CD, NMR, and HRESIMS.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research program is financially supported by the National Natural Science Foundation of China [grant number 21272278] and the National Mega-project for Innovative Drugs [grant number 2012ZX09301002-002].