A new drimane sesquiterpenoid and a new triterpene lactone from fungus of Fomes officinalis

Abstract

A new sesquiterpenoid fomeffic acid (1) and a new triterpene lactone fomefficinin (2) were isolated from the fungus Fomes officinalis, together with another six known compounds fomitopsin C (3), dehydrosulfurenic acid (4), dehydroeburiconic acid (5), dehydroeburicoic acid (6), 3-keto-dehydrosulfurenic acid (7), and laricinolic acid (8). The structures and stereochemistry of 1 and 2 were determined by NMR and X-ray diffraction analyses. The sesquiterpenoid and five triterpenes were tested for cytotoxicity against HL-60, Bel-7402, and KB cancer lines in vitro, and they appeared to be modestly active.

Keywords::

• Fomes officinalis
• sesquiterpenoid
• triterpene
• cytotoxicity

Acknowledgment

The authors thank Prof. Q.H. Liu (Xinjiang Institute of Materia Medica) for collecting plant material.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Financial support from National Natural Science Foundation of China [grant number NSC 20672146]; Hebei College Education Science Foundation of China [grant number 2011178]; Hebei Provincial Natural Science Foundation of China [grant number H2012206019] is gratefully acknowledged.