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Journal of Asian Natural Products Research Volume 17, 2015 - Issue 11
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Articles

Two new cassane-type diterpenes from the seeds of Caesalpinia crista

Qi-Bing LiuDepartment of Pharmacology, School of Pharmaceutical Science, Hainan Medical University, Haikou571199, ChinaView further author information
,
Ling HuangDepartment of Pharmacology, School of Pharmaceutical Science, Hainan Medical University, Haikou571199, ChinaView further author information
,
Li ZhangDepartment of Pharmacology, School of Pharmaceutical Science, Hainan Medical University, Haikou571199, ChinaView further author information
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Qiang LiuDepartment of Pharmacology, School of Pharmaceutical Science, Hainan Medical University, Haikou571199, ChinaView further author information
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Qiao-Qin XuDepartment of Pharmacology, School of Pharmaceutical Science, Hainan Medical University, Haikou571199, ChinaView further author information
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Xian-Jing QinDepartment of Pharmacology, School of Pharmaceutical Science, Hainan Medical University, Haikou571199, ChinaView further author information
,
Xing-Yue FangDepartment of Pharmacology, School of Pharmaceutical Science, Hainan Medical University, Haikou571199, ChinaView further author information
&
Yu ZengDepartment of Pharmacology, School of Pharmaceutical Science, Hainan Medical University, Haikou571199, ChinaCorrespondence[email protected]
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Pages 1073-1078 | Received 08 Mar 2015, Accepted 19 May 2015, Published online: 13 Aug 2015
 
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Abstract

Two new cassane-type diterpenes, phangininoxys D and E (1 and 2), together with five known compounds were isolated from the seeds of Caesalpinia crista Linn. The structures of these compounds were elucidated by means of various spectroscopic analyses. All the isolated compounds were evaluated for cytotoxicity activities against HeLa, HT-29 and KB cell lines, and compound 7 showed moderate selective activities against KB cell line with an IC50 value of 17.1 μM.

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Funding

This work was supported by the Natural Sciences Foundation of China [number 81460550]; Hainan Provincial Project of Modernization of Traditional Chinese Medicine [number ZY201426], [number ZY2012614]; Hainan Provincial Key Project of Science and Technology Program [number ZDXM2014070].

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