Two new sesquiterpenoids from cultures of the basidiomycete Tremella foliacea

Abstract

Two new sesquiterpenoids, trefoliol B (1) and trefoliol C (2), together with known echinocidin A (3), were isolated from cultures of the basidiomycetes Tremella foliacea. The new structures were elucidated on the basis of extensive spectroscopic methods. At the same time, trefoliol B (1) and echinocidin A (3) were tested for their cytotoxicities against five human cancer cell lines and for their inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD). No compound showed significant activity (IC₅₀ > 40 μM). Compound 1 showed moderate inhibitory activities against 11β-HSD1 (human IC₅₀ = 13.1 μM; mouse IC₅₀ = 91.8 μM).

Keywords::

• Tremella foliacea
• trefoliols B and C
• cytotoxicities
• 11β-HSD

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by National Natural Sciences Foundation of China [grant number 81373289], [grant number U1132607]; West Light Foundation of CAS [grant number 2013312D11016].