Highly oxygenated triterpenoids from the roots of Schisandra chinensis and their anti-inflammatory activities

Abstract

A new highly oxygenated triterpenoid, schinchinenlactone D (1), and three known compounds (2–4) were isolated from the roots of Schisandra chinensis. Their structures were determined by combining the spectroscopic analysis with the theoretical computations. The anti-inflammatory activities of compounds 1–4 were evaluated, and compound 3 exhibits the most significant activity in the inhibition of NO production with an IC₅₀ value of 10.6 μM.

Keywords::

• Schisandraceae
• Schisandra chinensis
• highly oxygenated triterpenoids
• anti-inflammatory activity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was funded by the National Basic Research Program (973) of China [grant number 2014CB138702] and the Fundamental Research Funds for the Central Universities [grant number lzujbky-2014-81].