A new bioactive steroidal ketone from the South China Sea sponge Xestospongia testudinaria

Abstract

A new steroidal ketone (1), with an ergosta-22,25-diene side chain, was obtained from the South China Sea marine sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of detailed spectroscopic analysis and by comparison with literature. Compound 1 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of type II diabetes and obesity, with an IC₅₀ value of 4.27 ± 0.55 μM, which is comparable with the positive control oleanolic acid (IC₅₀ = 2.63 ± 0.22 μM).

Keywords::

• Petrosiidae
• Xestospongia testudinaria
• sponge
• steroidal ketone
• PTP1B inhibitory activity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research work was financially supported by the Natural Science Foundation of China [grant number 81273430], [grant number 41306130], [grant number 81302692] and [grant number 41476063]; the National Marine ‘863’ Project [grant number 2012AA092105], [grant number 2013AA092902]; the China Postdoctoral Science Foundation [grant number 2012M520956], [grant number 2014T70443], SCTSM Project [grant number 14431901100]; and was partially funded by the EU 7th Framework Programme-IRSES Project [grant number 246987].