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Abstract
Bio-activity directed investigation of hexane extract from the leaves of Premna tomentosa led to the isolation of three new clerodane diterpenes (1–3) along with four known compounds (4–7). The structures of new compounds were established using IR, MS, 1D, and 2D NMR techniques. The in vitro cytotoxicity of the crude hexane extract and the isolated compounds were evaluated against seven human cancer cell lines and results indicated that compounds 2 and 4 depicted significant cytotoxicity against hepatocellular carcinoma cell line.
Acknowledgements
The authors are thankful to Dr M. Lakshmi Kantam, Director, Indian Institute of Chemical Technology, for her constant encouragement and support. This investigation was supported by the financial grant received from CSIR, New Delhi India under CSC 0130 (NaPAHA) project. ND acknowledges the financial assistance provided by ICMR-JRF fellowship. AD acknowledges the financial assistance provided by Ministry of Science & Technology, Govt of India 12th Five Year plan project CSC-0111 (SMilE).
Disclosure statement
No potential conflict of interest was reported by the authors.