Phenylpropanoids from the stems of Ephedra sinica

Abstract

Two new compounds of phenylpropanoids, (S)-N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-5-oxopyrrolidine-2-carboxamide (1) and (3R)-3-O-β-d-glucopyranosyl-3-phenylpropanoic acid (2), were isolated from the stems of Ephedra sinica. Their structures were elucidated by in-depth examination of spectroscopic data, mainly including those from the 1D and 2D NMR and HRESIMS techniques, and chemical method. The absolute configurations of the two compounds were also corroborated through CD procedure.

Keywords:

• Ephedra sinica
• Ephedraceae
• amphetamine-type alkaloid
• glycoside of phenylpropanoic acid

Acknowledgment

This work was financially supported by the National Natural Science Foundation of China under grant No. 81361138020 and the National Science and Technology Project of China under grant No. 2012ZX09301002001003.

Disclosure statement

No potential conflict of interest was reported by the authors.