Two new indole alkaloids from Hunteria zeylanica

Abstract

Two new indole alkaloids, 14β-hydroperoxy-eburnamine (1) and 18α-hydroxy-eburnamine (2), together with three known indole alkaloids, (-)-eburnamonine (3), (-)-eburnamenine (4), and eburnamine (5) were isolated from Hunteria zeylanica collected in Hainan Province of China. Their structures were determined by spectroscopic analysis. The relative configuration of 2 was deduced by NOE experiment and evidenced by the calculations for energy minimization with the molecular modeling program Chem3D Ultra 10.0.

Keywords:

• Apocynaceae
• Hunteria zeylanica
• alkaloids
• eburnamine

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was financially supported by National Basic Research Program of China (2014CB138703), the National Natural Science Foundation of China (31472144), the Natural Science Foundation of Gansu Province (145RJZA142) and the Fundamental Research Funds for the Central Universities (lzujbky-2014-79).

Additional information

Funding

This work was financially supported by National Basic Research Program of China [grant number 2014CB138703], the National Natural Science Foundation of China [grant number 31472144], the Natural Science Foundation of Gansu Province [grant number 145RJZA142] and the Fundamental Research Funds for the Central Universities [grant number lzujbky-2014-79].